Colchicine ( Colchicine Prevent Sudden) is the most specific treatment for acute gout attacks. In some European countries, oral colchicine is still used for the routine treatment of acute gout. Its selectivity is used as a diagnostic tool. It is also effective in treating acute attacks of cartilage calcification and, in some cases, other arthritic attacks (such as sarcoidosis). Colchicine appears to be adjunct prophylaxis needed to initiate treatment for hyperuricemia with uric aciduria or uric acid-dissolving agents to avoid acute gout due to sudden recruitment of the uric acid pool. In addition to gout, colchicine is the best drug for the treatment of familial Mediterranean fever.