Hyperuricemia and its clinical manifestations are common not only in patients with chronic renal failure but also in transplant patients. However, available treatments are generally forbidden or have a high risk of side effects, and there is currently no clear consensus on how to treat patients in this group. In the case of gout attacks, corticosteroids continue to be a safe and effective alternative unless there is an underlying infection. Although not currently recommended for the prophylactic treatment of hyperuricemia, allopurinol is a major component of disease modification therapy in patients with renal dysfunction and in patients with gout, even at reduced doses. Generally well tolerated. Adapt accordingly.